Drug release control systems make it possible to deliver the drug to the target tissue at a specified speed and at a specified time in a way that prevents adverse side effects on other components. A desirable method for this purpose is the use of synthetic polymer nano-carriers based on biocompatible and biodegradable polymers. In order to improve the loading and release efficiency of diclofenac, a starch-based polymer nanocomposite and polyvinyl alcohol were synthesized as biodegradable polymers and FeOOH nanoparticles and its application as a pharmaceutical structure in controlling drug release was investigated. We also used analyzes such as SEM, XRD and FTIR to characterize the synthesized nanostructures.