The electrooxidation of epinephrine (EPI) and piroxicam (PRX) has been investigated by application of nickel hydroxide nanoparticles/multiwalled carbon nanotubes composite electrode (MWCNTs-NHNPs/GCE) using cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CA) methods. The modified electrode showed suitable electrochemical responses for EPI and PRX determination. Under the optimum conditions the electrode provides a linear response versus EPI and PRX concentrations in the range of 1–220 µM and 0.7–75 µM, respectively using the DPV method. Linear responses versus EPI and PRX concentrations in the range of 1–1000 µM and 1–800 µM, respectively, were obtained using the CA method. The modified electrode was used for determination of EPI and PRX in human urine with satisfactory results.
