The synthesis of bioactive molecules with pharmacological activity is the main challenge of modern medicinal chemistry for the preparation of new drugs.1 It is crucial to choice inexpensive and green methods with the use of available starting materials for the synthesis of bioactive molecules. 2 Multicomponent reactions (MCRs) are among the most important reactions that are valuable tools for the synthesis of complex molecules. 3 Advantages such as operational simplicity, easy access to structural diversity, convergent specificity and atom economy have made MCRs as a powerful tool for modern drug discovery
