Abstract: In this study, a composite made of nano zeolite and hydrogel with some biodegradable polymers (polyethylene glycol, poly acrylic acid and polyacrylamid) was prepared and its controlled drug release was tested in phosphate buffer solution (with pH =7.8) and at temperature of 37°C which is similar to the human blood situation. The drug release rate over time was measured with UV spectrophotometer. Various percentages of nano zeolite were used and their effects on the controlled drug release were considered. A sample containing 3 wt.% zeolite had lowest rate of drug release. Distribution of particles in the polymer matrixes was studied by scanning electron microscopy (SEM) and their characteristics were identified by X-ray diffraction. The temperature and pH effects on the controlled drug release from hydrogel nano zeolite were investigated.
