Let $R$ be a commutative Noetherian ring with non-zero identity, $fa$ an ideal of $R$, and $X$ an $R$--module. Here, for fixed integers $s, t$ and a finite $fa$--torsion $R$--module $N$, we first study the membership of $Ext^{s+t}_{R}(N, X)$ and $Ext^{s}_{R}(N, H^{t}_{fa}(X))$ in the Serre subcategories of the category of $R$--modules. Then, we present some conditions which ensure the existence of an isomorphism between them. Finally, we introduce the concept of the Serre cofiniteness as a generalization of cofiniteness and study this property for certain local cohomology modules.
