The use of membranes in desalination and water treatment has been intensively studied in recent years. The conventional membranes however have various problems such as uncontrollable pore size and membrane properties, which prevents membranes from quickly responding to alteration of operating and environmental conditions. As a result the membranes are fouled, and their separation performance is lowered. The preparation of smart gating membranes inspired by cell membranes is a new method to face these challenges. Introducing stimuli-responsive functional materials into traditional porous membranes and use of hydrogels and microgels can change surface properties and membrane pore sizes under different conditions. This review shows potential of smart gating membranes in water treatment. Various types of stimuli-response such as those of thermo-, pH-, ion-, molecule-, UV light-, magnetic-, redox- and electro-responsive gating membranes along with various gel types such as those of polyelectrolyte, PNIPAM-based, self-healing hydrogels and microgel based-smart gating membranes are discussed. Design strategies, separation mechanisms and challenges in fabrication of smart gating membranes in water treatment are also presented. It is demonstrated that experimental and modeling and simulation results have to be utilized effectively to produce smart gating membranes.