The aim of this study was to consider the efficiency of the electro-Fenton process for organic compound reduction in an industrial dairy effluent. Experiments were conducted to evaluate the effect of several parameters, such as reaction time, pH, H2O2/Fe2+ molar ratio and volume fraction of H2O2 to dairy wastewater (mL/L), on the process performance. The Taguchi technique was applied to investigate the optimum operating conditions. The optimum chemical oxygen demand removal (93.24%) was experimentally obtained at a pH value of 7.58, reaction time of 87.13, current density of 58.5, H2O2/Fe2+ molar ratio of 3.62 and volume fraction of H2O2 to dairy wastewater of 1.39 mL/L.