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Niloufar Darbandi

Niloufar Darbandi

Academic rank: Associate Professor
ORCID: https://orcid.org/0000-0001-6888-8745
Education: PhD.
ScopusId: 24075112300
HIndex:
Faculty: Science
Address: Arak University
Phone:

Research

Title
Myricetin protects hippocampal CA3 pyramidal neurons and improves learning and memory impairments in rats with Alzheimer’s disease
Type
JournalPaper
Keywords
nerve regeneration; myricetin; Alzheimer’s disease; streptozotocin; hippocampus; pyramidal neurons; CA3 region; behavioral test; neural regeneration
Year
2016
Journal NEURAL REGEN RES
DOI
Researchers Matin Ramazani ، Niloufar Darbandi ، Fariba Khodagholi ، Azam Hashemi

Abstract

There is currently no treatment for effectively slowing the progression of Alzheimer’s disease, so early prevention is very important. Numerous studies have shown that flavonoids can improve memory impairment. The present study investigated the effects of myricetin, a member of the flavonoids, on intracerebroventricular streptozotocin induced neuronal loss and memory impairment in rat models of Alzheimer’s disease. Myricetin at 5 or 10 mg/kg was intraperitoneally injected into rats over 21 days. Control rats were treated with 10 mL/kg saline. Behavioral test (the shuttle box test) was performed on day 22 to examine learning and memory in rats. Immediately after that, hematoxylin-eosin staining was performed to observe the morphological change in hippocampal CA3 pyramidal neurons. Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer’s disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer’s disease.