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Mehdi Sohrabi haghighat

Mehdi Sohrabi haghighat

Academic rank: Assistant Professor
ORCID: https://orcid.org/0000-0001-5430-9159
Education: PhD.
ScopusId: 57074880700
Faculty: Science
Address: Arak University
Phone:

Research

Title
Abiraterone-Docetaxel scheduling for metastatic castration-resistant prostate cancer based on evolutionary dynamics
Type
JournalPaper
Keywords
Game Theory
Year
2023
Journal PLOS ONE
DOI
Researchers Mehdi Sohrabi haghighat ، atefeh Dries

Abstract

Patients with metastatic castration-resistant prostate cancer (mCRPC) are divided into three groups based on their response to Abiraterone treatment: best responder, responder, and non-responder. In the latter two groups, successful outcomes may not be achieved due to the development of drug-resistant cells in the tumor environment during treatment. To overcome this challenge, a secondary drug can be used to control the population of drug-resistant cells, potentially leading to a longer period of disease inhibition. This paper proposes using a combination of Docetaxel and Abiraterone in some polytherapy methods to control both the overall cancer cell population and the drug-resistant subpopulation. To investigate the competition and evolution of mCRPC cancer phenotypes, as in previous studies, the Evolutionary Game Theory (EGT) has been used as a mathematical modeling of evolutionary biology concepts.