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Malek Soleimani mehranjani

Malek Soleimani mehranjani

Academic rank: Professor
ORCID: https://orcid.org/0000-0003-4822-2617
Education: PhD.
ScopusId: 6505623754
Faculty: Science
Address: Arak University
Phone:

Research

Title
Utilizing platelet-rich fibrin bioscaffold at the graft site improves the structure and function of mice ovarian grafts
Type
JournalPaper
Keywords
angiogenesis • apoptosis • autotransplantation • inflammation • ischemia • mice • ovary • oxidative stress • platelet-rich fibrin bioscaffold • stereology
Year
2019
Journal regenerative medicine
DOI
Researchers Elham Shojafar ، Malek Soleimani mehranjani ، Seyed Mohammadali Shariatzadeh

Abstract

Aim: The effect of platelet-rich fibrin (PRF) bioscaffold on the structure and function of mice- autotransplanted ovaries was investigated. Materials & methods: Mice were divided into three groups: control, autografted and autografted + PRF bioscaffold. Angiogenesis, ovary histology and serum bio- chemical factors were assessed. Results: The total volume of the ovary, the number of follicles and the level of superoxide dismutase activity, total antioxidant capacity, IL-10, progesterone and estradiol were significantly higher in the autografted + PRF bioscaffold group compared with the autografted group. In the autografted + PRF bioscaffold group, angiogenesis was accelerated and apoptosis rate, IL-6, TNF-α, malondialdehyde concentrations were significantly lower compared with the autografted group. Conclu- sion: PRF bioscaffold improves the structure and function of mice-autografted ovary.