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Khalil Faghihi

Khalil Faghihi

Academic rank: Professor
ORCID: https://orcid.org/0000-0001-9884-1788
Education: PhD.
ScopusId: 6603751266
Faculty: Science
Address: Arak University
Phone:

Research

Title
Synthesis of superabsorbent hydrogel nanocomposites for use as hemostatic agent
Type
JournalPaper
Keywords
Hydrogel nanocomposites; highly porous hydrogel; hemostatic agent; hemocompatibility; hemostasis
Year
2016
Journal International Journal of Polymeric Materials and Polymeric Biomaterials
DOI
Researchers ZEINAB MIRZAKHANIAN ، Khalil Faghihi ، Hamid Reza Momeni ، Aboulfazl Barati

Abstract

Uncontrolled hemorrhage continues to be the major cause of death in trauma. In this study, the authors prepared hydrogel nanocomposites (HNCs) using three different nanoparticles, SiO2, natural clinoptilolite (nC), and Ca2þ-modified clinoptilolite (mC). Fast-swelling superabsorbent hydrogel was used as a matrix of NCs. The hydrogel and HNCs were characterized by FTIR, XRD, FE-SEM, and TGA. The hemocompatibility of HNCs was evaluated by hemolysis test and blood cells function. HNC formed a physical barrier by dehydrating the injury site and concentrating clotting factors. Additionally, highly charged nanoparticles, promoted local hemostasis by activating the intrinsic pathway of the blood coagulation cascade.