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Javad Sargolzaei

Javad Sargolzaei

Academic rank: Assistant Professor
ORCID: https://orcid.org/0000-0001-5366-2014
Education: PhD.
ScopusId: 57191348268
Faculty: Science
Address: Arak University
Phone:

Research

Title
The P53/microRNA network: A potential tumor suppressor with a role in anticancer therapy
Type
JournalPaper
Keywords
MiRNAsP53CancerApoptosisStemness
Year
2020
Journal Pharmacological Research
DOI
Researchers Javad Sargolzaei ، tahere etemadi ، Atee Alyasin

Abstract

MicroRNAs (miRNAs) are endogenous and small non-coding RNAs that have been identified as mediators of tumor suppression as well as stress responses mediated by p53 suppressors. MiRNAs may act as tumor suppressors under certain conditions. MiRNAs regulated by p53 may control the expression of processes such as cell cycle progression, cell survival, and angiogenesis. P53 activity and expression are also controlled by miRNA; consequently alterations in the p53-miRNA network may be essential for tumor initiation and progression. Future studies on the p53-miRNA network presumably would find it helpful in diagnostic and therapeutic approaches or as tools for various cancers.