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Farzad Bamdad

Farzad Bamdad

Academic rank: Associate Professor
ORCID: https://orcid.org/0000-0002-3900-0783
Education: PhD.
ScopusId: 23487653700
Faculty: Science
Address: Arak University
Phone:

Research

Title
Determination of Iproniazid by Flow Injection Analysis with Chemiluminescence Detection Based on the Oxidation of Luminol by Trichloroisocyanuric Acid and Sodium Dichloroisocyanurate
Type
JournalPaper
Keywords
iproniazid, chemiluminescence, flow injection analysis, trichloroisocyanuric acid, dichloroisocyanurate, luminol
Year
2009
Journal Journal of Food and Drug Analysis
DOI
Researchers Afsaneh Safavi ، Ghodratollah Absalan ، Farzad Bamdad

Abstract

A simple, rapid and accurate chemiluminescent method is described for the determination of iproniazid. The proposed method is based on the chemiluminescence (CL) generated during the oxidation of luminol by trichloroisocyanuric acid (TCCA) and sodium dichloroisocyanurate (SDCC) in alkaline medium. It was found that iproniazid could greatly enhance the CL intensity of the mentioned reactions. The detection limits (3σ) were 8.0 and 76 ppb of iproniazid for the TCCA-luminol and SDCC-luminol systems, respectively. The relative CL intensity was linear with the iproniazid concentration in the range of 50-1000 and 1000-2000 ppb for TCCA-luminol system, and 100-2000 ppb for SDCC-luminol system. The method was applied to the determination of iproniazid in a synthetic sample as well as in human serum with acceptable accuracy and precision.