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Ehsan Salehi

Ehsan Salehi

Academic rank: Professor
ORCID: https://orcid.org/0000-0003-4409-1242
Education: PhD.
ScopusId: 25643697300
Faculty: Engineering
Address: Arak University
Phone: 086-32625020

Research

Title
Biaxial electrospun nanofibers based on chitosan-poly (vinyl alcohol) and poly (Ɛ-caprolactone) modified with CeAlO3 nanoparticles as potential wound dressing materials
Type
JournalPaper
Keywords
Electrospinning Wound dressing CeAlO3 Hybrid nanofibers Chitosan Cephalexin
Year
2022
Journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI
Researchers Fatemeh Shahverdi ، Aboulfazl Barati ، Ehsan Salehi ، MOHAMMAD ARJOMANDZADEGAN

Abstract

A two-nozzle electrospinning method was employed to fabricate hybrid nanofibers based on chitosan/polyvinyl alcohol (CS/PVA), with a ratio of 50:50, and poly (Ɛ-caprolactone) (PCL). CeAlO3 nanoparticles were synthesized by combustion method and utilized to improve the nanofiber's properties for wound dressing application. Cephalexin (CFX), as an antibiotic model, was also incorporated into the hydrophilic nanofibers. X-ray diffraction showed an increase in crystallinity when CeAlO3-NPs were present in the nanofibers. Water vapor transmission rates in the samples were calculated as 22,017 and 2627 g m− 2 day− 1 , all within the normal range of ideal wound dressings. Mechanical studies revealed a 43 % and 85 % increase in tensile strength and modulus when CeAlO3-NPs were incorporated. In vitro drug release tests were conducted to simulate drug release, and the neat fibers showed faster release than the modified fibers. The MTT assay and cell morphology experiments showed that CeAlO3-NPs did not affect the nanofiber's biocompatibility and fibroblast cells could better grow, differentiate and cover the prepared hybrid scaffold surface compared to the neat fibers. Taking the results of our study into account, we believe the prepared nanofibrous has the potential for use as a low-cost, effective wound dressing.