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Alireza Karimi

Alireza Karimi

Academic rank: Professor
ORCID: https://orcid.org/0000-0001-5006-8642
Education: PhD.
ScopusId: 57217189368
Faculty: Science
Address: Arak University
Phone:

Research

Title
Design of nanostructure chitosan hydrogels for carrying zinc phthalocyanine as a photosensitizer and difloxacin as an antibacterial agent
Type
JournalPaper
Keywords
Photodynamic hydrogel Phthalocyanine Difloxacin Drug delivery Antimicrobial photosensitizer
Year
2020
Journal INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI
Researchers Fahimeh Bayat ، Alireza Karimi

Abstract

Here, we develop homogeneous hydrogel networks containing zinc tetraamino-phthalocyanine (ZnTAPc) as photosensitizer cross-linked with glutaraldehyde. The cross-linking process occurs via imine bond formation by reaction of NH groups of ZnTAPc and chitosan with aldehyde groups of the glutaraldehyde. Insertion of ZnTAPc interestingly increases its solubility in water medium. 2.0% and 4% w/w of the ZnTAPc were used with respect to chitosan polymer to generate hydrogel photosensitizer. FT-IR and UV–Vis spectroscopy, scanning electron microscopy, and rheological measurements were applied to evaluate the properties of the prepared hydrogels. Finally, difloxacin HCl was selected as a fluoroquinolone drug for the assessment of the drug release features of the made hydrogels. The difloxacin release was affected by the amount of ZnTAPc and pH medium. The activity of the hydrogels in photosensitizing process was considered by computing the rate of 1,3diphenylisobenzofuran adsorption reduction as a singlet oxygen chemical quencher.