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Akbar Mobinikhaledi

Akbar Mobinikhaledi

Academic rank: Professor
ORCID: https://orcid.org/0000-0002-9732-7282
Education: PhD.
ScopusId: 6701730547
Faculty: Science
Address: Arak University
Phone:

Research

Title
Efficient synthesis of some novel symmetrical and unsymmetrical pyridine bis-1,2,4-triazoles and bis-1,3,4-thiadiazoles
Type
JournalPaper
Keywords
triazole, thiadiazole, thiosemicarbazide, bis-heterocyclisation
Year
2014
Journal JOURNAL OF CHEMICAL RESEARCH
DOI
Researchers Naser Forougifar ، Akbar Mobinikhaledi ، Abdolhossein Rafiei

Abstract

A series of novel bis-1,2,4-triazoles and bis-1,3,4-thiadiazoles bearing pyridine rings was synthesised, by multistep reaction sequences, in good to high yields. Reaction of pyridine-2,5-bis- and pyridine-2,6-bis-carbohydrazides with alkyl- or aryl-isothiocyanates gave the corresponding bis(thiosemicarbazide) derivatives, which could be cyclised under strongly basic conditions to give novel pyridine bis(1,2,4-triazole-3-thiols). However, under strongly acidic conditions the corresponding bis(2-amino-1,3,4-thiadiazoles) were obtained. The synthetic routes and spectroscopic characterisation of the new compounds are reported.