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Akbar Mobinikhaledi

Akbar Mobinikhaledi

Academic rank: Professor
ORCID: https://orcid.org/0000-0002-9732-7282
Education: PhD.
ScopusId: 6701730547
Faculty: Science
Address: Arak University
Phone:

Research

Title
Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na3AlF6 as an Efficient Catalyst
Type
JournalPaper
Keywords
Aromatic aldehydes; Bbenzimidaazole; Catalyst; o-Phenylenediamine
Year
2014
Journal Iranian Journal of Pharmaceutical Research
DOI
Researchers Akbar Mobinikhaledi ، Ahmad Hamta ، Mehdi Kalhor ، Seyyed Mehdi Shariatzadeh

Abstract

Considerable attention has been focused on the synthesis of benzimidazoles due to having a broad spectrum of biological activities such as anti-parasitic, fungicidal, anti-thelemintic and anti-inflammatory activities. As a part of our research work in this area, a series of benzimidasole derivatives (3a-n) were synthesized in good to high yields by reaction of o-phenylenediamine and different aromatic aldehydes in the presence of sodium hexafluroaluminate, Na 3 AlF6 , as an efficient catalyst at 50 ◦ C. This environmentally benign and practical method offers several advantages, such as high yields, use of available catalyst, mild reaction conditions and easy workup. The antibacterial activity of these benzimidasoles was also evaluated using Staphylococcus aureus (mm) and Escherichia coli (mm) bacterial strain. All synthesized materials were characterized using IR and NMR spectroscopy as well as microanalyses data.