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Akbar Mobinikhaledi

Akbar Mobinikhaledi

Academic rank: Professor
ORCID: https://orcid.org/0000-0002-9732-7282
Education: PhD.
ScopusId: 6701730547
Faculty: Science
Address: Arak University
Phone:

Research

Title
Synthesis and antimicrobial activity of some novel substituted 1,2,4-triazoles bearing 1,3,4-oxadiazoles or pyrazoles (pages 1366–1370)
Type
JournalPaper
Keywords
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Year
2011
Journal Journal of Heterocyclic Chemistry
DOI
Researchers Mehdi Kalhor ، Akbar Mobinikhaledi ، AKBAR DADRAS ، Maryam Tohidpour

Abstract

Several derivatives of substituted 1,2,4-triazole bearing the pyrazole (or oxadiazole) ring were synthesized via the reaction of 2,4-dihydro-4-benzyl-5-(isomeric pyridyl)-3H-1,2,4-triazole-3-thione 1a–c with ethyl chloroacetate, hydrazine hydrate, and acetyl acetone (or CS2/KOH) in absolute ethanol. The intermediate then undergoes an intramolecular cyclization in acidic medium. The newly synthesized compounds 4a–c to 7a–c were characterized using IR, NMR, and MS Spectroscopy. Some of the synthesized compounds 4,5,7a–c were evaluated for their antibacterial and antifungal activities. Most of these compounds indicated activity comparable to Gentamycine. Also some of them are more active than Tolnaftate, a known antifungal drug. J. Heterocyclic Chem., (2011)