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Akbar Mobinikhaledi

Akbar Mobinikhaledi

Academic rank: Professor
ORCID: https://orcid.org/0000-0002-9732-7282
Education: PhD.
ScopusId: 6701730547
Faculty: Science
Address: Arak University
Phone:

Research

Title
Synthesis and Antibacterial Activity of Some 2-(Benzo[d]thiazol-2-ylamino)-5-(arylidene)thiazol-4(5H)-ones
Type
JournalPaper
Keywords
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Year
2012
Journal indian journal of pharmaceutical education and research
DOI
Researchers Akbar Mobinikhaledi ، Somayeh Faghihi ، Mohammadhossein Abnosi ، Seyyed Mehdi Shariatzadeh

Abstract

Treatment of 2-aminobenzothiazole (1) with chloroacetyl chloride in dry benzene gave N-(benzo[d]thiazol-2-yl)-2-chloroacetamide (3), which under reaction with potassium thiocyanate in refluxing acetone afforded 2-(benzo[d]thiazol-2-ylamino)thiaazol-4(5H)-one (4). 2- Benzothiazolylimino-5-(arylidene)thiazol-4(5H)-one derivatives (5a-m) were synthesized by reaction of (4) with appropriate aromatic aldehydes and assayed their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Streptococcus group D, E. coli, Proteus vulgaris and Klebsiella pneumoniae strains. The antibacterial activity of these compounds revealed that the Bacillus subtilis was the most sensitive strain to 5a, 5c, 5d, 5g, and 5m compared to other investigated bacterial strains.