Uncontrolled hemorrhage continues to be the major cause of death in trauma. In this study, the authors prepared hydrogel nanocomposites (HNCs) using three different nanoparticles, SiO2, natural clinoptilolite (nC), and Ca2þ-modified clinoptilolite (mC). Fast-swelling superabsorbent hydrogel was used as a matrix of NCs. The hydrogel and HNCs were characterized by FTIR, XRD, FE-SEM, and TGA. The hemocompatibility of HNCs was evaluated by hemolysis test and blood cells function. HNC formed a physical barrier by dehydrating the injury site and concentrating clotting factors. Additionally, highly charged nanoparticles, promoted local hemostasis by activating the intrinsic pathway of the blood coagulation cascade.
